Department of Natural Product Biosynthesis
Max Planck Institute for Chemical Ecology
Hans-Knöll-Straße 8, 07745 Jena, Germany
oconnor (at) ice.mpg.de
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Publications before 2010
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Bernhardt, P., O'Connor, S. E.* (2009) Tetrahedron Lett. 50, 7118-7120.
Aza-tryptamine substrates in monoterpene indole alkaloid biosynthesis.
Lee, H.-Y., Yerkes, N., O’Connor, S.E.* (2009) Chem. Biol. 16, 1225-1229.
Silencing of tryptamine biosynthesis for production of unnatural alkaloids in plant culture.
Runguphan, W. Maresh, J. J., O’Connor, S. E.* (2009) Proc. Natl. Acad. Sci. USA 106, 13673-13678.
Chemo-enzymatic synthesis of heteroyohimbine alkaloid stereoisomers.
Bernhardt, P., Yerkes, N., O’Connor, S. E.* (2009) Org. Biomol. Chem. 7, 4166-4168.
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Mechanistic advances in plant natural product enzymes.
Usera, A.R., O'Connor, S.E.* (2009) Curr. Opin. Chem. Biol. 13, 485-491.
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Opportunities in metabolic engineering to enable scalable alkaloid production.
Leonard, E., Runguphan, W., O’Connor, S., Prather, K. J. (2009) Nat. Chem. Biol. 5, 292-300.
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Opportunities for enzyme engineering in natural product biosynthesis.
Bernhardt, P., O’Connor, S. E.* (2009) Curr. Opin. Chem. Biol. 13, 35-42.
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Metabolic reprogramming of periwinkle plant culture.
Runguphan, W., O’Connor, S. E.* (2009) Nat. Chem. Biol. 5, 151-153.
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Synthesis of 4-, 5-, 6- and 7-azido tryptamines.
Friedrich, A., Brase, S., O’Connor, S. E.* (2009) Tetrahedron Lett. 50, 75-76.
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Elucidation of natural product pathways in plants.
O’Connor, S. E. (2009) for "Plant-derived natural products; Synthesis, function and application" Springer, A. E. Osbourn, V. Lanzotti, Ed.
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Bypassing stereoselectivity in the early steps of alkaloid biosynthesis.
Bernhardt, P., Yerkes, N., O'Connor, S. E.* (2009) Org. Biomol. Chem. 7, 4166-4168.
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Strictosidine Synthase: Mechanism of a Pictet-Spengler catalyzing enzyme.
Maresh, J., Giddings, L. A., Friedrich, A., Loris, E. A., Panjikar, S., Stockigt, J.*, Peters, B.*, O’Connor, S. E.* (2008) J. Am. Chem. Soc. 130, 710-723.
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Substrate specificity and diastereoselectivity of strictosidine glucosidase.
Yerkes, N., Wu, J., McCoy, E., Galan, M. C., Chen, S., O’Connor, S. E.* (2008) Bioorg. Med. Chem. Lett. 18, 3095-3098.
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O’Connor, S. E. (2008) Encyclopedia of Chemical Biology. WileyBlackwell, T. Begley Ed.
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Natural products from plant cell culture.
McCoy, E., O’Connor, S. E.* (2008) Prog Drug Res. 65, 331-70.
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Chemoselective derivatization of unnatural alkaloids in periwinkle.
Galan, M. C., McCoy, E., O'Connor, S. E.* (2007) Chem. Comm. 3249-3251.
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Rapid identification of enzyme variants for reengineered alkaloid biosynthesis in periwinkle.
Bernhardt, P., McCoy, E., O’Connor, S. E.* (2007) Chem. Biol. 14, 888-897.
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Redesign of a central enzyme in alkaloid biosynthesis.
Chen, S., Galan, M. C., Carla Coltharp, O'Connor, S. E.* (2006) Chem. Biol. 13, 1137-1141.
Directed biosynthesis of alkaloid analogs in the medicinal plant Catharanthus roseus.
McCoy, E., O'Connor, S. E.* (2006) J. Am. Chem. Soc. 128, 14276-14277.
Chemistry and biology of terpene indole alkaloid biosynthesis.
O'Connor, S. E.*, Maresh, J. M. (2006) Nat. Prod. Rep. 23, 532-547.
Semisynthesis of secologanin derivatives.
Galan, M. C., O'Connor, S. E.* (2006) Tetrahedron Lett. 47, 1563-1565.
Substrate specificity of strictosidine synthase.
McCoy, E., Galan, M. C., O'Connor, S. E.* (2006) Bioorg. Med. Chem. Lett. 16, 2475-2478.
Terpene indole alkaloid biosynthesis.
O'Connor, S. E.*, McCoy, E. M. (2006) Rec. Adv. Phytochem. 40, 1-22.
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publications prior to 2005:
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Cryptic chlorination a non-haem iron enzyme during cyclopropyl amino acid biosynthesis.
Vaillancourt, F. H., Yeh, E., Vosburg, D. A., O'Connor, S. E., Walsh, C. T. (2005) Nature 436, 1191-1194.
Hicks, L. M.; O'Connor, S. E.; Mazur, M. T., Walsh, C. T., Kelleher, N. L. (2004) Chem. Biol. 11, 327-335.
Aureolic acids: Similar antibiotics with different biosynthetic gene clusters.
O'Connor, Sarah (2004) Chem. Biol. 11, 8-10.
Couch, R., O'Connor, S. E., Seidle, H., Walsh, C. T., Parry, R. (2004) J. Bacteriol. 186, 35-42.
O'Connor, S. E., Walsh, C. T., Liu, F. (2003) Angew. Chem. Intnl. Ed. (2003), 42, 3917-3921.
Polyketide-nonribosomal peptide epothilone antitumor agents: the EpoA, B, C subunits.
Walsh, Christopher T.; O'Connor, Sarah E.; Schneider, Tanya L. (2003) J. Ind. Microbiol. Biotechnol. 30, 448-455.
Schneider, T. L., Walsh, C. T., O'Connor, S. E. (2002) J. Am. Chem. Soc. 124, 11272-11273.
O'Connor, S. E., Chen, H., Walsh, C. T. (2002) Biochemistry. 41, 5685-5694.
Formation of β-hydroxy histidine in the biosynthesis of nikkomycin antibiotics.
Chen, H., Hubbard, B. K., O'Connor, S. E., Walsh, C. T. (2002) Chem. Biol. 9, 103-112.
Epothilone biosynthesis: assembly of the methylthiazolylcarboxy starter unit on the EpoB subunit.
Chen, H., O'Connor, S., Cane, D. E., Walsh, C. T.
Chem. Biol. (2001), 8, 899-912.
Chen, H., Thomas, M. G., O'Connor, S. E., Hubbard, B. K., Burkart, M. D., Walsh, C. T. (2001) Biochemistry. 40, 11651-11659.
Probing the Effect of the Outer Saccharide Residues of N-Linked Glycans on Peptide Conformation.
O'Connor, S. E., Pohlmann, J., Imperiali, B., Saskiawan, I., Yamamoto, K. (2001) J. Am. Chem. Soc. 123, 6187-6188.
Effect of N-linked glycosylation on glycopeptide and glycoprotein structure.
Imperiali, Barbara; O'Connor, Sarah E. (1999) Curr. Opin. Chem. Biol. 3, 643-649.
Chemistry and biology of asparagine-linked glycosylation.
Imperiali, B., O'Connor, S. E., Hendrickson, T.,Kellenberger, C. (1999) Pure Appl. Chem. 71, 777-787.
A molecular basis for glycosylation-induced conformational switching.
O'Connor, S. E., Imperiali, B. (1998) Chem. Biol. 5, 427-437.
The conformational basis of asparagine-linked glycosylation.
Imperiali, B., O'Connor, S. E. (1998) Pure Appl. Chem. 70, 33-40.
Conformational Switching Asparagine-Linked Glycosylation.
O'Connor, S. E., Imperiali, B. (1997) J. Am. Chem. Soc. 119, 2295-2296.
Modulation of protein structure and function asparagine-linked glycosylation.
O'Connor, S. E., Imperali, B. (1996) Chem. Biol. 3, 803-812.